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Alli leakage, “gas with oily spotting” side effects

Alli Research

Alli — a weaker version of Roche Holding’s prescription drug Xenical, known generically as orlistat — is the first over-the-counter diet medication approved by the FDA.  Orlistat works by inhibiting the production of an enzyme that the body uses to break down fats for digestion. Because the drug is not well absorbed by the digestive system, it acts only while sitting in the gastrointestinal tract. When taken with a meal, orlistat blocks the body from absorbing approximately one-quarter of the fat consumed.

Did you know that about half the users of GlaxoSmithKline’s new diet drug Alli may experience gastrointestinal side effects, according to clinical trials conducted before the drug’s approval.   According to one-year clinical trials, between 35 and 55 percent of people who took the drug achieved a 5 percent or higher reduction in body mass. Upon ceasing treatment, a significant number of them regained up to 35 percent of the lost weight.

Alli Side Effects

Because Alli blocks the body from digesting fat, the body finds other ways to excrete the fat that has been consumed. This often occurs through feces, which may lead to the common side effects of loose stools, leakage and “gas with oily spotting,” according to the Alli web site.  Side effects longer than six months are possible.  To limit side effects, GlaxoSmithKline recommends that all Alli users limit their fat intake to a maximum of 15 grams per meal.  The company offers one final tip for users of Alli: “You may feel an urgent need to go to the bathroom. Until you have a sense of any treatment effects, it’s probably a smart idea to wear dark pants, and bring a change of clothes with you to work.”

Learn more about Alli in our Alli diet pill reviews:

European experts slam the launch of Alli

Alli indepth diet pill review

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Xenical

Xenical diet pills reviews

Xenical diet pills must be prescribed by a medical doctor only for those that are obese.    Xenical is a prescription weight loss medication used to help people lose weight when combined with a restricted diet and excerise.

The Xenical diet pill works by trying to block the body’s absorption of fat in your digestive system.  While some diet products claim to be “fat blockers” however; Xenical is the only prescription “fat blocker” diet pill.

Xenical is different from other diet pills that may work to effect the central nervous system to stimulate the brain to suppress your appetite.  Rather Xenical diet pills use a fat blocking mode of action that works non-systemically in the gastrointestinal tract.  Dietary fats are large molecules that must be broken down by enzymes, called lipases, before they can be absorbed into the bloodstream.  Xenical blocks or interferes with these pancreatic lipases in effect by forming covalent bonds with the them in the stomach and small intestine, this essentially inactivates the enzymes so they are no longer available to hydrolyze dietary fat into an absorbable state. Thus, allowing up to an estimated 33 percent of dietary fats to pass through the gastrointestinal tract unchanged.
Xenical Diet pill facts

Xenical diet pills are only prescription based and must be doctor prescribed and only for those that are obese or extremely over-weight.  However, Xenical diet pills do have uncomfortable side effects and may not work for all dieters.  For example dieters with low fat diets may not experience much if any benefits form Xenical diet pills.  Also, dieters that are switching to healthier low fat diets would have the same little to no effect from Xenical with such diets.

 
Xenical Side Effects

Xenical diet pills have side effects and the bad news is that Xenical’s side effects are even more pronounced early on in the use of Xenical.   Consumers report loose and oily stools with increase flatulence (wind) with discharge and even staining.  The increased bowel movements are due to Xenical diet pills excess fat in the loose stool that may discharge as dirrea.  In order to avoid Xenical diet pills related embarrassment doctors usually recommend the following dosing regimen begin treatment by taking one 120mg Xenical with low to medium fat content meals and observe changes in your bowel movements.   Of course, if you are already eating low fat meals the Xenical diet pills will have less effect and need.

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Alli

Alli Reviews

Xenical – Orlistat – Alli:  all versions of the same drug but do they really work?  And is the all new new Alli weight-loss drug worth it?

  CDR Experts Alli Take
     
Xenical – Orlistat – AlliAll versions of the same drug but do they really work?  While Alli is now available in stores, it only comes in a much lower dose of one-half of prescription fat-blocking drug Xenical also known as orlistat, under the marketed brand name Alli. Alli only offers modest results and can cause embarrassing side effects. 
 

If it’s over the counter weight loss pills you’re after, you can now buy Alli, also know by its ingredient name orlistat.  Orlistat is a fat-blocking drug of limited effectiveness, now available in stores without a prescription.  Recently the Food and Drug Administration gave Orlistat’s manufacturer, GlaxoSmithKline the approval to sell an over-the-counter version of the drug under the brand name AlliHowever, Alli is only half the dose of prescription orlistat, Xenical, which has been on the market since 1999.

With the recent FDA approval, GlaxoSmithKline Alli recent massive marketing will likely capture a chunk of the $41 billion that Americans spend on weight-loss products each year. The company says Alli, which recenly hit store shelves, will cost $1.80 per day.  But if a pill that limits your body’s ability to absorb fat from food seems a little too good to be true, you’re on to something. Alli, the drug does have embarassing if not uncomfortable drawbacks.

To begin with, Xenical, the prescription version of Alli at twice the dose, hasn’t lived up to its promise; some doctors have found it to offer marginal benefit in clinical practice. At half the prescription strength, Alli is likely to be even less effective. Data presented to the FDA suggest that Alli works best in those who are very overweight, that it must be used in conjunction with a low-fat, reduced-calorie diet, and that results are modest.  In Alli’s clinical trials, severely overweight subjects who took the drug for six months lost about 5 pounds more than those taking a placebo. In a separate four-month Alli trial, moderately overweight people lost about 2 1/2 pounds more than the control group. Benefits are also likely to be short-lived. Alli is marketed for short-term use only, and follow-up suggests that people start to regain weight once they stop taking it.

Embarrassing side effects

Alli or Orlistat is notorious for what one FDA advisory panel member termed “the underwear problem.” Unabsorbed fat can cause intestinal side effects such as fatty stools, oily spotting, flatulence with discharge, an urgent need to defecate, and frequent bowel movements.

Evidence suggests that the drug can also impede the absorption of fat-soluble vitamins. Users need to take a multivitamin daily at least two hours before or after taking orlistat, though in actual-use studies only about half managed to do so. Orlistat should not be used by those taking the blood thinner warfarin (Coumadin). People on diabetes medications should use it only under a doctor’s supervision.

The OTC Alli diet pill packaging includes a guide to healthful eating with Alli starter packs.  But while the healthful eating advice might be worth taking, are the Alli pills worth the price?

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