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Public Health Alert Update: Counterfeit Alli containing sibutramine

The U.S. Food and Drug Administration (FDA) is updating its warning to the public about a counterfeit version of Alli 60 mg capsules (120 count refill pack) being sold over the internet, particularly at online auction sites like eBay. FDA advises people who believe that they have a counterfeit product not to use the drug.

Alli is an FDA-approved over-the-counter weight loss drug that contains orlistat as its active ingredient.  The counterfeit version of Alli does not contain orlistat; rather, it is made with varying amounts of sibutramine, a stimulant drug.

Although sibutramine is the active ingredient in another FDA-approved prescription weight loss drug, it is only to be used in specific doses and under the supervision of a physician. The counterfeit product is illegal and unsafe.

Additional FDA laboratory tests on the counterfeit product show that people may be taking 3-times the usual daily dose (or twice the recommended maximum dose) of sibutramine if they are following the dosing directions for Alli. Healthy people who take this much sibutramine can experience anxiety, nausea, heart palpitations, tachycardia (a racing heart), insomnia, and small increases in blood pressure. This excessive amount of sibutramine is dangerous to people who have a history of cardiovascular disease, and can lead to elevated blood pressure, stroke, or heart attack.

FDA recommends everybody check and make sure they are not taking counterfeit Alli. If they suspect they are taking the counterfeit product, they should stop taking the drug. People should contact their healthcare professionals if they have taken the counterfeit product and are experiencing more than mild side effects, especially if they have a history of cardiovascular disease.

Although the counterfeit product looks very similar to Alli, this product can be identified by:

A missing LOT code on the outer cardboard packaging.  An expiration date that includes a MONTH, DAY, and YEAR — the expiration date of the real product only contains a MONTH and a YEAR.   A plain foil for the inner safety seal without any words on it — the safety seal of the real product has the words “SEALED FOR YOUR PROTECTION” prominently printed on it.  The counterfeit product will also contain large capsules with white powder, as opposed to the small white pellets found in Alli.  People can also compare the product they bought over the internet to one purchased at a pharmacy. The plastic bottle of the counterfeit product will be slightly taller, have a wider cap, and coarser ribbing on the cap then what is seen with authentic Alli.
People who believe they have received counterfeit Alli can contact GSK if they believe they have purchased the counterfeit product.  Consumers are encouraged to report adverse events that may be related to the use of these counterfeit products

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